Engineers have sent proton particles all the way round the Large Hadron Collider (LHC) machine for the first time in more than a year, BBC reported.
But they still do not have a stable circulating beam; this step is expected to happen after 0600 GMT on Saturday.
The LHC is housed in a 27km-long circular tunnel some 100m beneath the French-Swiss border.
It will smash together beams of protons in a bid to shed light on the nature of the Universe.
The LHC has been shut down for repairs since an accident in September 2008.
Operated by the European Organization for Nuclear Research (Cern), the LHC will create similar conditions to those which were present moments after the Big Bang.
We have no idea where the chinks in our understanding of the Universe are going to become apparent
Dr Tara Shears, University of Liverpool
What is the Large Hadron Collider?
Q&A: Repairs to the LHC
There are some 1,200 "superconducting" magnets arranged end-to-end in the underground tunnel.
These magnets bend proton beams in opposite directions around the main "ring" at close to the speed of light.
At allotted points around the tunnel, the proton beams cross paths, smashing into one another with enormous energy. Scientists will scour the wreckage of the collisions for discoveries that should extend our knowledge of physics.
On Friday evening, engineers sent a beam around the LHC's 27km-long ring for the first time since September 2008. Engineers are expected to continue sending protons around the collider overnight.
The beams themselves are made up of "packets" - each about a metre long - containing billions of protons. The protons would disperse if left to their own devices. So once beams are circling the LHC, they have to be stabilised.
This involves using electrical forces to "capture" the protons, keeping them tightly huddled in packets.
The LHC was designed to run at energies of seven trillion electron volts. But the machine will clash together protons at energies of just 3.5 trillion electron volts (TeV) in its first few months of operation.
Beam sent round Big Bang machine
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