Duke University scientists now have identified these "silenced genes," creating the first map of this unique group of about 200 genes believed to play a profound role in people's health. More intriguing, the work marks an important step in studying how our environment - food, stress, pollution - interacts with genes to help determine why some people get sick and others do not. "What we have is a bag of gold nuggets," lead researcher Dr. Randy Jirtle said about the collection of "imprinted" genes. The team's findings were published online Friday by the journal Genome Research. Usually, people inherit a copy of each gene from each parent and both copies are active, programmed to do their jobs whenever needed. If one copy of a gene becomes mutated and quits working properly, often the other copy can compensate. Genetic imprinting knocks out that backup. It means that for some genes, people inherit an active copy only from the mother or only from the father. Molecular signals tell, or "imprint," the copy from the other parent to be silent. Only animals that have live births have imprinted genes. It was not until 1991 that it was proved that humans had them. Until now, only about 40 human imprinted genes had been identified. Many of the newly found imprinted genes are in regions of chromosomes already linked to the development of obesity, diabetes, cancer and some other major diseases, the researchers reported. One, for example, appears to prevent bladder cancer. A second appears to play a role in causing various cancers and may affect epilepsy and bipolar disorder. Previous work by Jirtle and others shows the environment can reprogram how some genes operate, making them speed up or slow down or work at the wrong time. In a groundbreaking 2003 experiment, Jirtle fed pregnant mice different nutrients to alter the coat color of their babies. The feed affected chemical signals that control how hard a certain gene worked, determining when the babies had yellow coats like mom or brown ones. Sometimes imprinting goes awry before birth, leaving a normally silenced gene "on" or silencing one that should not be. Faulty gene imprinting leads to some devastating developmental disorders, such as Angelman syndrome, which causes mental retardation. Now a question is how imprinting may be changed to reactivate an imprinted gene after birth.
Duke scientists map ' silenced genes '
30 November 2007 09:53 (UTC+04:00)