(news.bbc.co.uk) - Unlike the Oscars, the Globes - handed out by the Hollywood Foreign Press Association - have separate categories for dramas, and comedies or musicals.
Movies like The Departed, United 93, and Letters from Iwo Jima are drama frontrunners while Little Miss Sunshine is a favourite for best comedy.
The winners will be announced at a ceremony in Los Angeles on 15 January.
Clint Eastwood is also attracting praise for his World War II drama Flags of our Fathers, continuing his run of critical success with Mystic River and Million Dollar Baby.
But many are tipping its companion piece, the Japanese-language film Letters from Iwo Jima, for the main prizes. Starring Ken Watanabe, the film has already won best film from Los Angeles Film Critics' Association.
Two 11 September dramas are in the running for nominations, but Paul Greengrass's United 93 took a lead over Oliver Stone's World Trade Center when it recently won the New York critics' prize.
Crime thriller The Departed was directed by Martin Scorsese who, despite his immense reputation as a film-maker, has never won an Oscar - some may feel his time has come to be recognised.
Other possible contenders for the comedy award are Stranger Than Fiction, the Oscar spoof For Your Consideration and fashion-industry satire The Devil Wears Prada.
Yet to be released in the UK, the Motown-era musical Dreamgirls has also attracted critical attention, including praise for stars Eddie Murphy American Idol finalist Jennifer Hudson.
Helen Mirren as Queen Elizabeth II in The Queen and Forest Whitaker as Idi Amin in The Last King of Scotland are considered favourites for the top dramatic acting nominations.