Under Secretary of State for Political Affairs Wendy Sherman and her team will travel to Geneva, Switzerland, on Thursday to hold negotiations with Iranian officials, the State Department said on Wednesday.
"These bilateral consultations will take place in the context of the P5+1 nuclear negotiations with Iran," it added.
It noted that Deputy Secretary General for the European Union's External Action Service Helga Schmid would also join the bilateral talks.
The new round of talks will come as Iranian Foreign Minister Mohammad Javad Zarif and US Secretary of State John Kerry have held meetings multiple times mostly in European capitals.
The last face-to-face meeting between Zarif and Kerry was held in the German city of Munich earlier this month, when they met twice on separate days on the sidelines of an international security conference.