One official, who spoke on condition of anonymity because he was not authorized to talk to the media, told Reuters most guests had been evacuated from the five-star Pearl Continental Hotel but attackers appeared to have reached the first floor.
Gwadar, which lies on the Arabian Sea, is a strategic port being developed as part of the $60 billion China Pakistan Economic Corridor, which is part of China’s mammoth Belt and Road infrastructure project.
Balochistan Home Minister Ziaullah Langove said there appeared to be casualties but there were no immediate details.
There was no immediate claim of responsibility.
Balochistan is rife with ethnic, sectarian and separatist insurgencies, and several militant groups operate in the province, including the Pakistani Taliban group or Tehrik-i Taliban Pakistan (TTP) and Balochistan Liberation Army.