Peruvian Prime Minister Yehude Simon left office on Friday after presenting his resignation earlier this week to Peruvian President Alan Garcia, Xinhua reported.
The outgoing prime minister has said he would run for the presidency in 2011, but his political future was overshadowed by a deadly clash between the police and Amazon natives last month.
Simon said he had already fulfilled his role of paving the way for the new prime minister to address the issue.
At least 34 people died after police clashed with native protesters demanding the government scrap laws that violated their rights by encouraging foreign investment in mining and oil development in the rainforest.
"I said that I would leave the office once the country was in peace and I think I have fulfilled it," Simon said.
Garcia announced on Tuesday a cabinet reshuffle but it remains unknown who will replace Simon.