Dozens of people were protesting in Gaza City on Thursday at an anti-Islam film that has sparked violence in Egypt and Libya, dpa reported.
Witnesses said the protesters burnt US and Israeli flags and chanted, "Death to America! Death to Israel!"
They also burnt black-and-white pictures of a person believed to be the producer of the film. Some young men waved black flags of the Popular Resistance Committees (PRC), a radical armed faction active in Gaza.
The protest was in Gaza City's Rimal neighbourhood, which houses the headquarters of international organizations such as UNRWA, the UN agency that assists Palestinian refugees, the UN's Office for the Coordination of Humanitarian Affairs and the World Health Organization.
International organizations shut their offices for one day as a precautionary measure.
The United States has no representation in Gaza.t has a consulate in East Jerusalem.