Tehran is waiting for US president-elect Barack Obama to put into practice his "Yes We Can" slogan, Foreign Ministry Spokesman Hassan Ghashghavi said in a press briefing Monday.
The spokesman said that Tehran would reply favourably to any change of policy by Washington towards Iran.
For the first time since the 1979 Islamic revolution, an Iranian president sent a congratulation message to his American counterpart on his success in the presidential race, reported dpa.
Iranian President Mahmoud Ahmadinejad congratulated Obama last Thursday for "having been able to attract the majority of votes in the elections" and hoped he would "leave a good name by moving in the line of people's real interests."
Obama indicated in a press conference that he would reply to the Iranian president.
Tehran hopes the time is ripe to put an end to almost three decades of political hostility, especially since the president-elect had during his campaign indicated willingness to hold direct talks with Tehran.
The major issues between the two countries are Tehran's controversial nuclear programmes, non-acknowledgement of Israel by Tehran as a sovereign state, Iran's support for anti-Israeli militia groups such as Lebanon's Hezbollah and the Palestinian territory's Hamas and the current situation in Afghanistan and Iraq.
Ghashghavi further said that Iran was evaluating an offer by European Union foreign policy chief Javier Solana to hold another meeting with Iran's chief nuclear negotiator Saeid Jalili
Although Iran still insists on going on with its nuclear projects, including uranium enrichment, Tehran is ready to hold talks with the five United Nations veto powers plus Germany (5+1) to seek a settlement of the dispute.
Observers believe that Iran would prefer talks with the 5+1 after Obama's presidency begins in January so the new US administration would be present in the talks.