The Syrian government offered amnesty to those "misled into unlawful activities" who come forward within two weeks, state-run media reported on Monday, dpa reported.
The announcement comes amidst an ongoing crackdown against anti- government protesters in the country.
The Ministry of Interior called on "those who carried weapons and threatened the country's security" to turn themselves over, in exchange for amnesty by May 15.
Ib a statement carried by state-run news agency SANA, the ministry also urged people to come forward and provide information about "outlaws, terrorists, and the location of weapons storages."
The Syrian government has repeatedly blamed foreign infiltrators, armed gangs, and extremist groups for the widespread protests calling for political reforms in the country.
Security forces arrested dozens of activists and dissidents in the southern city of Daraa, activists said online.
Daraa been under siege by the military since last week, and has had its electricity, water supplies, and communications networks interrupted, according to activists.
Gunshots could be hear in the southwestern city of Duma Monday, where widespread arrests were also taking place, according to the Facebook group Syrian Revolution 2011.
Rights groups say more than 600 people are feared dead in the violent crackdowns by Syrian security forces against protesters since March 15.
Protesters in Syria are demanding political reforms and an end to the rule of Bashar al-Assad and his Ba'ath Party.