Palestinian Prime Minister Rami Hamdallah has submitted his resignation, sources in his office confirmed Thursday, two weeks after being sworn in, dpa reported.
It was not immediately clear whether Palestinian President Mahmoud Abbas accepted the resignation.
Hamdallah cited "infringement on his authority" as the reason for his decision, the sources said.
They said Hamdallah was unable to get along with his two deputies, Muhammad Mustafa and Ziad Abu Amr, who were appointed to their posts by Abbas against Hamdallah's wishes.
Abbas chose the 54-year-old academic for the post after premier Salam Fayyad stepped down in April after six years in the position.
Hamdallah and his 24-member cabinet - most of which were holdovers from Fayadd's government - were sworn in on June 6.
It was intended to be a caretaker government that would serve until mid-August, when the secular Fatah party in the West Bank and the Islamist Hamas movement in the Gaza Strip are due to form a unity government.
Fatah leader Abbas is then to head the unity government comprised of independent technocrats, which is suppose to pave the way for presidential and legislative elections.
The rival Fatah and Hamas movements have agreed to unity deals but failed to implement them.
Hamdallah is an independent who has served as president of Najah University in the West Bank city of Nablus since 1998.