At least 27 people were killed across Egypt on Friday, the health ministry said, in clashes between security forces and loyalists of deposed Islamsit president Mohamed Morsi, Ahram reported.
Health ministry sources said four were killed in clashes in the Suez Canal city of Ismailiya and further eight in Damietta.
A makeshift hospital in Cairo's in Cairo's Ramses Square, where Morsi supporters are converging, has put the deaths there at 42.
Unofficial reports from witnesses claimed a higher tally in several cities.
Violence broke out as thousands of Islamists marched in several cities across Egypt in what they dubbed a "Friday of anger" to protest Wednesday's crackdown on pro-Morsi protest camps which left more than 600 people dead and thousands others wounded.