Riot police in the Sudanese capital, Khartoum, used live ammunition and tear gas in an attempt to disperse protesters marching towards the presidential palace, Trend reports referring to Aljazeera.
Videos posted online appeared to show crowds of several hundred people heading towards the palace on Tuesday, which is located on the bank of the river Blue Nile in the heart of Khartoum.
The demonstrators could be heard singing patriotic songs and chanting, "Peaceful, peaceful against the thieves" and "The people want to bring down the regime" before police began firing into the crowds.
The unrest came after five days of rallies against the government of President Omar al-Bashir, with protesters enraged over rising prices, shortage of basic goods and a cash crisis.
Al Jazeera's Hiba Morgan, reporting from Khartoum, said calls for the president to step down were growing louder with people turning up in significant numbers for the protest, which had been planned for a number of days.
"[Protesters] seemed to agree they want to see change and the police had to use tear gas and live ammunition to disperse the crowd," Morgan said.
"Unfortunately, for the police that is, people continued [marching]. We've heard people say they want the 'regime' to go, they want to see a new 'regime.'"
"Even with the tear gas being fired at them, some people have been using headscarves and went on to proceed against the riot police with their demands that the president must leave."