Pakistani Foreign Minister Shah Mehmood Qureshi on Sunday called for an immediate end to Israel's air and ground operation in the Gaza Strip, saying the loss of life was unjustified, AFP reported.
The offensive, launched more than a week ago by Israel in response to a wave of rockets fired from the Gaza Strip run by the Islamist Hamas movement, has killed over 463 people so far.
Rocket fire from Gaza over the same period has killed four Israelis.
"There should be an immediate ceasefire in Gaza. We should stop the loss of life and property there," Qureshi told a press conference in the central city of Multan, broadcast live on state television.
"What has happened is unjustified and Pakistan has condemned it."
He said Pakistan had spoken out against the Israeli attacks in the 57-member Organisation of the Islamic Conference (OIC), which on Saturday urged the UN Security Council to take action to put a stop to the strikes.
In New York, the Council failed to agree on a resolution calling for an immediate ceasefire after hours of closed-door talks.
Pakistani President Asif Ali Zardari said last week that the Israeli strikes were counterproductive and violated the UN charter.
Protesters rallied in several cities across Pakistan on Friday after main weekly Muslim prayers against Israel's operation in Gaza, with some burning Israeli flags, and calling for jihad, or holy war, against the Jewish state.