Washington has imposed sanctions on Venezuela's Conviasa Airline, the US Treasury Department said, Trend reports citing Sputnik.
The new sanctions also target 40 of Conviasa's aircraft, the Treasury Department's Office of Foreign Assets Control said in a notice on its website.
Conviasa is the largest airline of Venezuela, operating services to domestic destinations and throughout South America and the Caribbean.
The statement comes after a US official said that Washington is confident that increased pressure on the Maduro government will create the opportunity for a transition of power.
US President Donald Trump and Venezuelan opposition leader Juan Guaido are scheduled to meet at 2:15 p.m. EST (7:15 p.m. GMT) on 12 February at the White House to discuss facilitating a transition of government in Venezuela.