Cristiano Ronaldo plays against his former club as record winners Real Madrid were on Thursday drawn to play Manchester United in the last 16 of the European Champions League, dpa reported.
Former Real player Steve McManaman drew the English team to play the Spanish champions at the UEFA headquarters in Nyon, Switzerland. Ronaldo played at United until leaving for Real for a world record fee in 2009.
The two sides have met in four ties on the biggest European stage, with Real winning three of them, the last in the 2003 quarter-finals.
AC Milan v Barcelona is another major tie at the start of the knockout stages, with the first leg games scheduled for February 12/13 and 19/20, the return legs for March 5/6 and 12/13.
Barca and Milan last met in the 2012 quarters, with Lionel Messi and company prevailing 3-1 on aggregate.
Another big tie pits Arsenal against the 2012 runners-up Bayern Munich, Galatasaray play Schalke, Celtic take on Juventus, Shakhtar Donetsk face Borussia Dortmund, Valencia meet Paris St Germain and Porto play debutants Malaga.