A helicopter carrying Mexican Interior Minister Francisco Blake crashed in the south of Mexico City on Friday, media reports said, Reuters reported.
Blake, 45, was traveling between Mexico City and the state of Morelos just to the south, his ministry said.
Mexico is locked in a brutal conflict against drug cartels that has killed 45,000 people in the last five years and Blake is a key member of President Felipe Calderon's security team.
Mexico's peso weakened to 13.42 pesos per dollar on the news. It was not clear whether Blake, who took office in July 2010, had survived the crash or what caused it.
Blake would be the second Mexican interior minister in Calderon's presidency to be involved in an aviation accident.
In November 2008, Juan Camilo Mourino and several other people died when their small plane crashed next to a major Mexico City boulevard during rush hour.