Egyptian protesters blocked the road to Cairo's airport on Sunday, delaying US Secretary of State John Kerry's departure for around two hours after his two-day visit to Egypt, DPA reported.
Kerry was due to leave to Saudi Arabia at 1400 GMT, but his flight was delayed for around two hours, airport officials said.
Security forces secured Kerry's motorcade, which included 16 vehicles, and changed its course to let him into the airport through another entry.
As protesters brought traffic in both directions to a standstill, passengers were seen leaving cars and walking to the airport in order to catch their flights.
The protest by the Ultras groups come ahead of the planned handing down on March 9 of court verdicts for 52 defendants involved in a deadly football riot last year that left 74 dead.
In January, a court sentenced 21 people to death in the case. The ruling sparked clashes in the north-eastern city of Port Said, leaving some 40 people dead.
Kerry was in Cairo as part of the Middle East leg of his first trip abroad. The visit comes as Egypt sees a widening rift between its Islamist president Mohammed Morsi and the mostly secular opposition.
The US diplomat met with Morsi and Defence Minister Abdel-Fattah al-Sissi on Sunday, as well as representatives of non-governmental organizations.
A military source told Al-Ahram newspaper that al-Sissi stressed to Kerry that the armed forces have no role in the political rift in the country and will not take sides.
On Saturday, Kerry called for political participation and compromise between the Islamist-led government and the secular-dominated opposition, which is boycotting the country's upcoming parliamentary election, due to start on April 22.
The opposition accuses Morsi of tightening the Muslim Brotherhood's hold on power and failing to revitalize the ailing economy. His Islamist allies accuse the opposition of wanting to oust Morsi, Egypt's first civilian president.
Washington was a key ally to the regime of Hosny Mubarak, who was toppled in an uprising two years ago after three decades in power.
Kerry was in Turkey on Friday after visiting several European capitals. He is expected to visit the United Arab Emirates before concluding his tour in Qatar.