Clues to alcohol cancer mystery

A genetic discovery could help explain why some people who drink too much develop cancers, while others do not.

A European study, published in Nature Genetics, has found two gene variants which offer "significant" protection against mouth and throat cancers, BBC reported.

It suggested that people who have them are much better at breaking down alcohol into less harmful chemicals.

Cancer Research UK said cutting down on the amount you drink is the best way to prevent cancer.

More than seven out of ten people diagnosed with mouth cancers drink more than the recommended alcohol limit - and, alongside smoking, it is also a known risk factor for oesophageal cancer.

Previous research had identified a group of genes called ADH as clear candidates for a role in the development of these cancers.

These genes make body chemicals which help break down alcohol, and, in theory, the more effective these are, the less opportunity alcohol has to damage the cells in the mouth and throat.

Led by the International Agency for Research on Cancer in Lyon, France, the research team looked at 9,000 cases of people of similar ages and lifestyles who either developed mouth and throat cancers, or didn't.

They found two variants in the group of ADH genes were linked to a lower chance of getting cancer.

Looking only at study participants who admitted drinking heavily, the potentially beneficial effect of having one of the variants was even more pronounced, in line with the amount of alcohol consumed.

It is already known that people with one of the gene variants can break down alcohol more than 100 times faster than those who did not have it, and the study authors said this suggested that this process was key in protecting people from alcohol-linked throat and mouth cancer.

However, other experts pointed out that having the variant did not offer a licence to drink heavily.

Hazel Nunn, from Cancer Research UK, said: "This interesting piece of science, but people with these genetic variants who drink alcohol are still at higher risk of these cancers than non-drinkers.

"More work will be needed to examine the precise role of these genetic variations in the development of cancer.

"The best practical advice for reducing the risk of cancers of the mouth, pharynx, larynx and oesophagus remains to stop smoking and drink less alcohol.

"Alcohol is also linked to cancers of the breast, bowel and liver. The more you cut down on alcohol, the more you reduce your risk."

Subscribe to Trend in Google News! Subscribe
Saipem to adopt Honeywell Forge software to create digital twin
Saipem to adopt Honeywell Forge software to create digital twin
Iberostar to purchase 10 tons of hydrogen
Iberostar to purchase 10 tons of hydrogen
Oil prices fall as weaker China growth, U.S. output stoke demand concerns
Oil prices fall as weaker China growth, U.S. output stoke demand concerns
Loading Bars
Latest
India, US, Israel & UAE coming together to form a 2nd Quad?
Azerbaijani army starts command post exercises in Lachin district
Iranian currency rates for October 19
Iran makes investments in oil and gas fields in Ilam Province
Saipem to adopt Honeywell Forge software to create digital twin
Iberostar to purchase 10 tons of hydrogen
Uzbekistan completes construction of new airport in Sokh district
Karabakh’s rivers must be cleaned up before return of population – Azerbaijani deputy minister
Russia, Azerbaijan progressively developing co-op in agriculture – Russian ministry
Black Sea Trade and Development Bank launching new tender
India, Israel to start talks on free trade agreement next month
Baku International Sea Trade Port sees increase in cargo transshipment for 9M2021
Mexico to begin packaging Sputnik V vaccine in second half of November
Oil prices fall as weaker China growth, U.S. output stoke demand concerns
Turkmenistan’s enterprise launches filament lamps production
Germany might offer its experience in restoration of Azerbaijan’s Karabakh
Toshkent Metro to be under jurisdiction of Transport Ministry of Uzbekistan following presidential decree
Top U.S. envoy to Afghanistan stepping down
Georgia reveals TOP-10 of largest energy consumers in country
Over 70% of Iranians already received first dose of COVID-19 vaccine - Iranian President
Iran's ministry shares financial data on backing its industrial, mining enterprises (Exclusive)
COVID-19: Kazakhstan adds over 1,300 fresh cases in 24h
N.Korea fires ballistic missile as military activity surges
Algeria lifts lockdown nationwide amid drop in COVID-19 cases
Road crash kills 11 in Ecuador
Turkey summons envoys of 10 countries over Kavala statement
Gunmen kill at least 43 in northern Nigeria - state governor
Apple introduces M1 Pro, M1 Max chips
Number of COVID-2019 cases across globe exceeds 240 mln
Morocco police seize over one tonne of cocaine in Tangier port
Latvia announces four weeks of lockdown as COVID-19 cases spike
Chronicles of Victory: President Ilham Aliyev interviewed by Russian TASS news agency on October 19, 2020 (PHOTO/VIDEO)
Chronicles of Victory: October 19, 2020
Occupation Museum, Memorial Complex and adjacent Victory Park will be built in Fuzuli
Israel congratulates Azerbaijan on Independence Restoration Day
Turkish President congratulates Azerbaijan on Independence Restoration Day
Tigray forces say air strikes hit Ethiopia's Mekelle, government denies
Czech president too ill to work, politicians discuss relieving him of duties
PMs discuss Belarus-Kazakhstan economic cooperation
Pentagon chief says US values Georgia as strategic partner
Azerbaijan's flag illuminated on TV tower in Georgia due to anniversary of restoration of Azerbaijan's independence (PHOTO)
Iran unveils details of its trade turnover with Oman
Bahar Azadi gold coin price continues to fall in Iran
Iran’s Lavan Oil Refining Company reveals products on sale at IRENEX
Post Bank of Iran sees increase in revenues
Price of Turkmen gas supplied to China grows - Wood Mackenzie
Turkey's Presidential Administration congratulates Azerbaijan on Independence Restoration Day
Azerbaijan shares data on number of vaccinated citizens
Azerbaijan confirms 1,245 more COVID-19 cases, 409 recoveries
Georgia and US sign Memorandum of Understanding
Uzbekistan Railways expanding transport, logistics co-op with sea and dry ports
Azerbaijan to hold new auction for state property facilities
Saudi fast-food franchise operator Alamar Foods considers IPO
French ambassador makes statement on occasion of Azerbaijan's Independence Restoration Day
German companies interested in expanding economic co-op with Azerbaijan
EU has exported over 1 bln COVID-19 vaccines
U.S. manufacturing output declines in September
Azerbaijan issues startup certificates to more SMEs
Uzbekistan’s private airline launches flights from Tashkent to Moscow
Iran eyes resuming import of Turkmen gas
Azerbaijan's Khudafarin bridge in Jabrayil district - finally liberated (PHOTO)
Azerbaijan’s renewable energy potential exceeds installed capacity fourfold
Kazakhstan to extend food import substitution measures amid COVID-19
Ukraine has every capability to restore infrastructure of Azerbaijan’s liberated territories – MP
Playtech acquired for $3.7b
Total value of Azerbaijan's oil export abroad up in 9M2021
Georgia to further develop relationship with Azerbaijan - Georgian MFA
EU Special Representative for South Caucasus to visit Azerbaijan
Iran records decrease in production of raw steel, steel products
Weekly review of Azerbaijani precious metals market
Turkish MoD congratulates Azerbaijan with its Independence Restoration Day
Ukrainian companies may partake in construction, restoration of Azerbaijan’s Aghdam – MP
Azerbaijan's announces drastic increase in car imports for 9M2021
Pan-European Executive MBA designed specifically to integrate holistic approach to business (VIDEO)
NATO ready to support ensuring peace in South Cacasus region - special rep
Non-OPEC oil output to more than half from 2020 levels
Weekly review of Azerbaijani currency market
Iran reveals COVID-19 data for October 18
Israel and Azerbaijan are great allies and partners, who have common interest in region – former Israeli MP
European renewables generation to exceed 6,000 TWh
Over 60% of total investment to be spent on developing new oil & gas fields
Iran’s NICICO boosts extraction and production
Azerbaijan Automobile Federation organizes 'Time Attack' race (PHOTO)
Azerbaijan's foreign trade turnover increases in 9M2021
Year passes since Azerbaijan's liberation of Khudaferin bridge from Armenian occupation (PHOTO/VIDEO)
EU gas production falls by 8%
Share of renewables in EU power generation mix decreased
North Carolina declares Oct. 18 as Day of Restoration of State Independence of Azerbaijan
MUSIAD aims to raise trade turnover between Azerbaijan and Turkey (VIDEO)
EU gas consumption reaches highest level in last seven years
EIB, EU Commission ink deal on financing for alternative fuels infrastructure projects
Armenia’s failure to provide minefield maps to Azerbaijan impedes restoration work in liberated territories - FM
Azerbaijan sees no effective steps from Armenia in opening transport links - minister
Azerbaijan recommends revanchist forces not to go down wrong path - PM
TAP updates on progress in market test
Azerbaijan stands for normalizing relations with Armenia in post-conflict period based on int'l law - FM
Turkey reveals cargo traffic with Netherlands for 8M2021
Master plans for Zangilan, Gubadli, Kalbajar and Lachin being prepared, will be done without taking any loans - Azerbaijani president
Khudaferin Bridge is proof of talent of Azerbaijani people - President Ilham Aliyev (VIDEO)
Physical gas flows, nominations at TAP’s interconnections
All news