Real Madrid became the latest major casualty in the Champions League when they nine-time European winners crashed out Wednesday to Italians Roma. ( dpa )
The Serie A side enjoyed a 2-1 victory in the Santiago Bernabeu for a 4-2 aggregate triumph, leaving Madrid going out at the last-16 stage again, as they did last season at the hands of Bayern Munich.
Real follow seven-time winners AC Milan, the reigning champions who were unceremoniously ousted Tuesday by Arsenal, as casualties in the first knock-out round of the competition.
The Spanish champions, who last won the trophy in 2002, had defender Pepe sent off after a second yellow card in the 71st minute as they slid to defeat.
Roma twice struck the post or bar - through Alberto Aquilan and Mirko Vucinic in each half - before Rodrigo Taddei headed the opening goal two minutes after Pepe's dismissal.
Raul Gonzalez got Real back into the game two minutes after but Vucinic - a 65th-minute substitute - made absolutely sure in stoppage time with a header from a Christian Panucci free-kick which this time sailed in under the bar.
Chelsea joined Premier League rivals Arsenal and Manchester United into the quarter-finals with a comfortable 3-0 victory over Greek side Olympiakos.
Goals from Michael Ballack, Frank Lampard and Salomon Kalou extended Chelsea's unbeaten home run to 60 matches to put the Blues into the last eight for the fourth time in the last five seasons.
After the goalless draw in Greece two weeks ago, Germany midfielder Ballack got Chelsea off to a perfect start when he headed in Lampard's cross from close range in the fifth minute.
Lampard then mopped up from close range 20 minutes later after goalkeeper Antonis Nikopolidis could only parry a Ballack shot.
Kalou made it three from close range three minutes after the break when the visitors failed to deal with a Lampard corner headed on by Ricardo Carvalho.
England could have four teams in the last eight if Liverpool prevail at Inter Milan next Tuesday, holding a 2-0 lead from the first leg.
Porto and Germany's Schalke 04 went into extra-time after Lisandro Lopez scored a goal four minutes to cancel out the visitors' 1-0 home win.