The detainees are suspected of money laundering, power abuse, bribery, forgery, as well as fraud in public procurement.
"The operation was undertaken in order to counter financial crime and corruption, particularly related to the state bodies," Stefanovic said Saturday during a press conference.
In total, 80 officials have caused damage to Serbia of almost $110 million since 2004.
The local police are set to detain at least 39 corrupt officials in the coming days.