The river overflowed early Monday following heavy rains on Sunday, triggering "devastating floods", affecting Mayo-Danay and Logone-et-Chari divisions, according to Oumara Maliki, prefect of Mayo-Danay division.
"The situation is still very disturbing and difficult. People have lost everything they worked for. We are still to evaluate what has been destroyed," Maliki said.
"We have cases of malaria, typhoid, and diarrhoea. We also have people who have been injured because buildings fell on them. We are trying to save them with very limited resources," he added.
Rescue missions are searching for missing persons, according to authorities, fearing the flooding impacts could be aggravated by high levels of food insecurity and the degree of poverty in the region.