In one of his strongest remarks against the Taliban, Afghan President Hamid Karzai condemned Saturday evening the attacks that killed scores of people over the last two days, dpa reported.
At least 31 people have been killed since Friday in four separate security incidents across the country.
Karzai called the attacks "acts of terror" and "mass killings."
"Taliban leaders and their commanders will be held accountable before the Afghan Muslim nation," Karzai said in a statement by his palace.
In the past Karzai has condemned the civilian deaths by the Taliban, while trying to court them calling "brothers who are lost."
But this is the first instance where he said the leaders and commanders of the insurgent movement would be held responsible.
"Taliban have recently become so desperate and incapable that they can't do anything but resort to targeting civilians, and especially innocent workers, engineers, women and children," the statement said, quoting Karzai.
"This once again proves that they have nothing to offer but killing and destruction."
On Saturday morning, a suicide bomber killed at least six people and injured 22 at a private bank in southern province of Kandahar.
"There are policemen among the dead and wounded," an official at the Kandahar state hospital said, asking not to be named.
"People were standing in front of the Kabul Bank branch to get their salaries, when the bomber on foot blew himself up," said Javed Faisal, spokesman for Kandahar provincial governor.
Most of the dead and injured are civil servants, with some policemen among them as well, he said, but did not give exact numbers.
In Sangin district of southern province of Helmand, 12 civilians were killed in a roadside bomb Friday night, while five young boys, shepherding their cattle, were killed in Doshi district of Baghlan province by a similar bomb.
Eight people including a district governor were killed Friday morning when a suicide bomber detonated his explosives at the gate of a mosque in the northern province of Kunduz.
This week, the Taliban have upped their attacks across the country. Militant attacks have left more than 65 people dead and over 100 injured in Afghanistan this week alone.