The airspace above the German capital Berlin was to be closed Wednesday as of 11 am ((0900 GMT), as ash from the Icelandic volcano Grimsvotn reached the region, airport authorities said, DPA reported.
Germany's air traffic control agency DFS already blocked all takeoffs and landings in Bremen beginning at 5 am (0300 GMT) and Hamburg beginning at 6 am (0400 GMT). First flights to and from Berlin have also been cancelled, an airport spokesman said.
The ash cloud on Tuesday affected air traffic across Europe, causing cancellations of about 500 flights. British airports were worst hit.
A year ago, a volcano that erupted under the Eyjafjallajokull glacier caused major disruptions to air traffic in Europe, with thousands of flights grounded over the course of several weeks.