A plane carrying an estimated 112 crew and passengers crashed Friday at Kisangani airport in the Democratic Republic of Congo, with officials saying "dozens" of people were killed and injured, DPA reported.
At least 40 people are thought to have been pulled alive from the wreckage. The lethal crash is the latest in a series in the country.
"Our thoughts are firstly with the victims and their families," airline Hewa Bora said in a statement, but declined to give an exact death toll.
More than 30 airlines in the DR Congo, including Hewa Bora, are subject to a European Union ban, owing to safety concerns.
A rescue operation was still under way as night fell. Airline officials indicated by telephone that confirmed figures would likely only be released in the morning.
The plane was landing when it crashed at the airport, east of the capital Kinshasa, with poor weather being blamed for the accident.
The airline has a record of deadly crashes in the country, with one at Goma's airport in early 2008 killing at least 40 people, while another later in the year left 17 dead.
This year, in April, a UN jet crashed while trying to land in Kinshasa, killing 32 people.