The Large Hadron Collider is set to start the work that could lead to the discovery of fundamental new physics, BBC reported.
Scientists working on the European machine will attempt to smash beams of proton particles together at unprecedented energies.
On Tuesday morning, an abnormal electrical signal caused the inbuilt protection system to shut down the LHC.
Engineers are investigating the cause of this signal and hope to achieve the first collisions after 1230 BST.
The seven-trillion-electronvolt (TeV) collisions will initiate 18-24 months of intensive investigations at the LHC.
Scientists hope the study will bring novel insights into the nature of the cosmos and how it came into being.
But they caution that the data gathered from the sub-atomic impacts will take time to evaluate, and the public should not expect immediate results.
"Major discoveries will happen only when we are able to collect billions of events and identify among them the very rare events that could present a new state of matter or new particles," said Guido Tonelli, a spokesman for the CMS detector at the LHC.
"This is not going to happen tomorrow. It will require months and years of patient work," he told BBC News.