Experimental drug shows promise against brain, prostate cancers

Experimental drug shows promise against brain, prostate cancers

An experimental drug currently being tested against breast and lung cancer shows promise in fighting the brain cancer glioblastoma and prostate cancer, researchers at University of Texas Southwestern Medical Center have found in two preclinical studies, Xinhua reported.
   The drug's actions, observed in isolated human cells in one trial and in rodents in the other, are especially encouraging because they attacked not only the bulk of the tumor cells but also the rare cancer stem cells that are believed to be responsible for most of a cancer's growth, said Jerry Shay, professor of cell biology and a senior co-author of both papers.
   The glioblastoma study appears in the January issue of Clinical Cancer Research. The prostate cancer study is available online on Monday in the International Journal of Cancer.
   In the glioblastoma study, performed in mice, the drug also crossed from the bloodstream into the brain, which is especially important because many drugs are not able to cross the blood-brain barrier.
   "Because it attacks a mechanism that's active in most cancers, it might prove to be widely useful, especially when combined with other therapies," said Shay.
   Shay and his colleagues study telomeres, bits of DNA that help control how many times a cell divides. Telomeres are protective " caps" of DNA on the ends of chromosomes, the structures that contain the body's genes. As long as telomeres are longer than a certain minimum length, a cell can keep dividing. But telomeres shorten with each cell division, so a cell stops dividing once the telomeres are whittled down to that minimum.
   In cancer cells, however, an enzyme called telomerase keeps rebuilding the telomeres, so the cell never receives the cue to stop dividing. In essence, they become immortal, dividing endlessly.
   The drug used in these studies (imetelstat or GRN163L) blocks telomerase. It is already in clinical trials as a potential treatment for breast and lung cancer, as well as for chronic lymphocytic leukemia.
   Glioblastomas are the most common malignant brain tumors in adults, according to the American Cancer Society. They are difficult to treat with drugs because blood vessels in the brain have tightly constructed walls that allow only a few substances to pass through.
   The researcher focused on cells called tumor-initiating cells. Some researchers believe that tumors contain a small subset of initiating cells -- or cancer stem cells -- that are able to initiate and drive tumors and that are often resistant to radiation therapy and chemotherapy.
   In the glioblastoma study, Shay and his colleagues found that imetelstat blocked the action of telomerase in isolated tumor- initiating cells as well as the bulk of the tumor cells, eventually killing the cells. Combining imetelstat with radiation and a standard chemotherapy drug made imetelstat even more effective.
   When the researchers implanted human tumor-initiating cells into rodents, they found that imetelstat was able to enter brain tissue and inhibit telomerase activity.
   In the prostate cancer study, the researchers isolated tumor- initiating cells from human prostate cancer cells. The cells showed significant telomerase activity. Imetelstat blocked the enzyme's activity, and telomeres shortened greatly.

Afghanistan asks Tajikistan to increase power supply
Afghanistan asks Tajikistan to increase power supply
EU would like new EPCA to enhance regional co-op in Central Asia
EU would like new EPCA to enhance regional co-op in Central Asia
Uzbekistan resumes work of customs post on border with Tajikistan
Uzbekistan resumes work of customs post on border with Tajikistan
Loading Bars
Latest
Iran’s FM to visit Azerbaijan
COVID-19 vaccinations in Turkey exceed 1 million in 1st week
CBI Governor says part of Iranian frozen assets released
Georgian Parliament calls Pension Agency Head for transparency
Kyrgyzstan receives COVID-19 diagnostic reagents from Russia
Trump leaves Washington, skips incoming president Biden's inauguration
Blast rocks building in downtown Madrid
Azerbaijan shows footage from Nadirkhanli village of Kalbajar district (PHOTO/VIDEO)
Africa’s COVID-19 death toll tops 80,000, reports WHO
French online newspaper publishes article about January 20 tragedy
Memory of victims of January 20 tragedy honored in Azerbaijan’s Shusha city (VIDEO)
Turkish Foreign Ministry honors memory of Azerbaijani martyrs of January 20, 1990 tragedy in Baku
Turkish Ministry of National Defense talks January 20, 1990 tragedy in Baku
Azerbaijan confirms 897 more COVID-19 recoveries
Iran unveils amount of saved money by major mining companies
Anniversary of January 20 tragedy marked in Azerbaijan's Shusha
Events of Jan.20, 1990 divided life of Baku citizens into "before" and "after"
Kazakhstan bans import of Azerbaijani tomatoes
Review of Georgian exports to China
Azerbaijani troops hold several events in connection with January 20 tragedy (PHOTO/VIDEO)
Georgia increases wine exports to Azerbaijan
Azerbaijan becomes Georgia's second export partner
Kazakhstan reports decrease in mutual trade volume with Vietnam
Geostat reveals data on China's exports to Georgia
Iran reveals COVID-19 data for January 20
Turkey mobilized to support Azerbaijan in post-war period, says ambassador
Uzbek-Korean JV names volume polyethylene output in 2020
Container shipping rates surge in Georgia
Passenger transportation volume by road surges in Kazakhstan
Georgia may lift restrictions on international flights
Georgia sees decrease in electricity consumption
January 20 events of 1990 aimed to strangle Azerbaijan’s fight for independence – historian
Turkmenistan’s Mary State Power Plant names production indicators of 2020
Iran dismisses having any 'secret talks' with Biden's team to bring US back to JCPOA
New geopolitical reality following Karabakh war to make contribution to GDP growth in Azerbaijan - Economy Minister
Iran to commit to JCPOA obligations - if Europe, US return - FM Zarif
Commerzbank deepens partnership with Microsoft
Central Bank reveals volume of property appropriated by Georgian commercial banks
Kazakhstan's Baikonur Cosmodrome starts launching works for 2021
Azerbaijani Kapital Bank’s total assets increase as of 2020
Carnations blooming today along with khari bulbul in Azerbaijan – Turkish FM
Exports of Iran's steel products declines
French ambassador to Azerbaijan talks about January 20 tragedy
Turkmen carpet weaving enterprise reveals production volume
Iran may cancel additional protocol on nuclear deal - Foreign Policy Commission
Azerbaijan keen to develop relations with Turkey, Pakistan in almost all spheres
Azerbaijani people honoring memory of 20 January tragedy victims (PHOTOS)
Caspian Shipping Company’s marine flotilla reveres memory of January 20 martyrs (VIDEO)
Armenians destroyed mausoleum of outstanding Azerbaijani poet in Shusha - monitoring results
Azerbaijan's State Service for Property Issues unveils amount of transfers to state budget
Supply of Indian manufactured vaccines to neighbouring and key partner countries
Azerbaijan progresses with cotton yields in 2020
EU's Michel calls on Biden to form new transatlantic pact
Jewish community in Azerbaijan revere memory of victims of January 20 tragedy
India to gift 2 mn doses of Covid-19 vaccine 'Covishield' to Bangladesh
India, Japan sign Memorandum of Cooperation to help promote movement of skilled workers
Georgia reports 469 new COVID-19 cases for Jan.20
UK ambassador to Azerbaijan makes statement on January 20 tragedy
Benefits provided for Uzbek entrepreneurs likely to be extended
Share of domestic exports up in Georgia
Azerbaijan discloses number of mandatory health insurance services in 2020
Azerbaijani president, first lady visit Alley of Martyrs on 31st anniversary of 20 January tragedy (PHOTO)
India, Oman Hold Discussions On Bilateral Cooperation
Turkmenistan's Turkmengas to buy chemical products via tender
Uzbekistan, Turkey to work on approving agreement on preferential trade
Azerbaijan’s Kapital Bank reveals 2020 net profit
EU Delegation mourning victims of “Black January” tragedy - statement
Copper ores and concentrates top export goods in Georgia
Azerbaijan holds minute of silence to honor January 20 victims (PHOTOVIDEO)
Modi gets SOS message for vaccine from Caribbean nation that stood by India
Black January means symbol of struggle for independence - Charged ’Affairs of Azerbaijani Embassy in Ethiopia
Iran’s South Pars Gas Company beats new record on export
First Vice- President Mehriban Aliyeva shares Instagram post on 20 January tragedy (PHOTO)
Uzbekistan’s Central Bank to place bonds on republican currency exchange
Georgia sees decrease in external merchandise trade
Turkmenistan's Mary region opens tender for construction
Turkmenistan signs contract for aircraft purchase from French Airbus
UK inflation rises a little more than expected in December
Largest share of mortgage loans falls on Uzbekistan’s Samarkand region
Article on Black January tragedy of Azerbaijani Consul General in LA published
EU4Business supports expansion of Georgia’s biggest digital creative agency to global markets
Кazakh Electricity Grid Operating Company to buy construction materials via tender
Azerbaijani oil prices continue to grow
Phased COVID-19 vaccination continues in Azerbaijan - Ministry of Health
Kazakh Embassy extends condolences to Azerbaijan on 20 January tragedy's anniversary
Number of Uzbek banks raise dollar rate
EBRD names loans volume provided for Uzbekistan during COVID-19
EBRD, State Electricity System of Georgia implement new energy project
Uzbekistan names start date for vaccination against COVID-19
Azerbaijani Ministry of Agriculture holds meeting on results of cotton growing dev't (PHOTO)
Azerbaijani company reveals growth in 2020 total insurance revenues
Aide to Azerbaijani president shares post on Twitter on anniversary of 20 January tragedy (VIDEO)
As always, on Day of National Mourning, we mourn with Azerbaijan - Turkish Embassy
Iran, Cuba joint COVID-19 vaccine to begin new phase of testing in Havana
Iran, Iraq discuss transit operations
Electricity generation potential of Iran's Kerman Province announced
Russia's Gazprom increases purchases of natural gas in Turkmenistan
Azerbaijan applying innovations for agrochemical soil analysis
Turkic Council commemorates heroes of Azerbaijan on occasion of 20 January tragedy anniversary
Azerbaijan to ease the health protocols for Iranian transit and export trucks
All news